文章核心观点 - 公司在第二季度取得了重要进展,包括继续推进临床项目,并计划在2024年底启动RLY-2608与Pfizer新型CDK4抑制剂阿替莫西克利的三联疗法临床试验[5] - 公司还披露了三个新的临床前项目,包括血管畸形、法布里病和NRAS靶向项目,这将有助于公司的持续增长和多元化[5][9][10] 关于RLY-2608 - RLY-2608双联疗法:继续在PI3Kα突变、HR+、HER2-局部晚期或转移性乳腺癌患者中进行400mg BID和600mg BID剂量扩展队列的入组,预计2024年第四季度将有更新数据[7] - RLY-2608三联疗法:继续在PI3Kα突变、HR+、HER2-局部晚期或转移性乳腺癌患者中进行RLY-2608+芙维司特兰+利博西克利三联疗法的入组,并宣布与辉瑞合作评估RLY-2608+阿替莫西克利+芙维司特兰三联疗法,计划于2024年底启动[7] - RLY-2608单药:继续在有PI3Kα突变的不可切除或转移性实体瘤患者中进行剂量递增部分的入组,并报告了多种肿瘤类型中的部分缓解反应[7] 关于其他项目 - 公司终止了与Genentech合作开发migoprotafib的协议,不会继续开发该项目[7] - 公司计划在2025年第一季度启动RLY-2608在血管畸形适应症的临床开发,2025年下半年启动法布里病和NRAS靶向项目的临床开发[11] 财务情况 - 截至2024年6月30日,公司拥有6.884亿美元的现金、现金等价物和投资,预计可为公司运营提供资金支持到2026年下半年[12] - 2024年第二季度研发费用为9,200万美元,较2023年同期增加,主要是由于RLY-2608ReDiscover试验的额外外部成本[13] - 2024年第二季度管理费用为2,010万美元,与2023年同期持平[14] - 2024年第二季度净亏损为9,221万美元,每股亏损0.69美元,较2023年同期有所改善[15]

DUBLIN, Aug. 06, 2024 (GLOBE NEWSWIRE) -- Trinity Biotech plc (Nasdaq: TRIB), a commercial stage biotechnology company focused on human diagnostics and diabetes management solutions, including wearable biosensors, obtained an extension to demonstrate compliance with a continued listing requirement of The Nasdaq Global Select Market. As previously reported in a Current Report on Form 6-K filed November 29, 2023, the Company received a deficiency letter from the Listing Qualifications Department of The Nasdaq ...

NEW YORK, Aug. 06, 2024 (GLOBE NEWSWIRE) -- Today, Working Not Working Inc., a Fiverr company (NYSE: FVRR) and the leading platform for creative talent discovery, released the top findings from its first ever (un)Happiness Survey to better understand how creatives are really feeling about their jobs at a time when the industry is focused on adopting new technologies and optimizing literally everything except their people. The report, which features survey responses from nearly 1,000 full-time creative profe ...

HONOLULU, HI, Aug. 06, 2024 (GLOBE NEWSWIRE) -- To support ongoing wildfire relief efforts following last year's tragic wildfires in Maui, Verizon is donating $10,000 to the Maui Food Bank. This funding will supply essential resources to Maui Food Bank's program, Da Market, by enhancing the inventory of fresh produce, nutritious nonperishable items, and vital household goods. This ensures that families in West Maui affected by the wildfires have ongoing access to healthy and culturally appropriate food opti ...

RESTON, Va., Aug. 06, 2024 (GLOBE NEWSWIRE) -- NextNav (NASDAQ:NN), a leader in next generation positioning, navigation, timing (PNT) and 3D geolocation, announced today that the Federal Communications Commission (FCC) released a public notice seeking comment on its innovative spectrum solution in the Lower 900 MHz band (902-928 MHz band). On April 16, NextNav filed a rulemaking petition asking the FCC to open this proceeding to reconfigure the Lower 900 MHz band and adopt new rules to enable a terrestrial ...

Caesars' petition for new hearing before the high court is denied in case centering on deal to bring new multimillion-dollar gaming technologies to market LAS VEGAS, Aug. 6, 2024 /PRNewswire/ -- The Nevada Supreme Court has denied a request from Caesars Entertainment to reconsider a case involving Tipping Point Gaming (TPG). TPG had been working closely with Caesars Entertainment (NASDAQ: CZR) to bring new gaming technology to market. Caesars now faces a new trial on fraud claims, amongst other tort claims, ...

More than 35 ways to dine and drink, resort-style pools, waterslides and more, combined with top destinations, set the stage for the boldest vacations in Europe for summer 2025 MIAMI, Aug. 6, 2024 /PRNewswire/ -- Vacationers can mark their calendars for a new way to adventure in Europe when Royal Caribbean International debuts a newly amplified Allure of the Seas in April 2025. The gamechanger is set for a more than $100 million encore of epic proportions that will combine bold experiences and must-see dest ...

MORTON GROVE, Ill., Aug. 6, 2024 /PRNewswire/ -- Lifeway Foods, Inc. (Nasdaq: LWAY) ("Lifeway" or "the Company"), a leading U.S. supplier of kefir and fermented probiotic products to support the microbiome, today announced it will report financial results for the second quarter ended June 30, 2024 on August 13, 2024 before market hours. A pre-recorded conference call and webcast with Julie Smolyanksy, Lifeway's President and Chief Executive Officer, discussing these results with additional comments and deta ...

TORONTO, Aug. 06, 2024 (GLOBE NEWSWIRE) -- Sprott Inc. ("Sprott" or the "Company") (NYSE/TSX: SII) announced today that its Board of Directors has declared a second quarter 2024 dividend of US$0.25 per common share, payable on September 3, 2024 to shareholders of record at the close of business on August 19, 2024. Registered shareholders who are residents of Canada as reflected in the Company's shareholders register, as well as beneficial holders (i.e., shareholders who hold their common shares through a br ...

NEW YORK, Aug. 6, 2024 /PRNewswire/ -- The Volkswagen brand has extended their global creative contract with Omnicom's DDB for another three years which has been Volkswagen's creative agency for over six decades. The partnership between Volkswagen and DDB has produced some of the greatest and most effective creative work in history, including DDB's famous "Think Small" and "Lemon" VW Beetle campaigns which launched in 1959. Volkswagen, DDB, and Omnicom continue to partner More recently, DDB and other key Om ...