Shares of Wave Life Sciences (WVE) surged 74.1% on Wednesday after the company reported positive proofof-mechanism data from an ongoing early to mid-stage study of its investigational candidate, WVE-006, for alpha-1 antitrypsin deficiency (AATD), a type of genetic disorder. WVE-006 is a GalNAc-conjugated oligonucleotide that enables A-to-I RNA editing and is administered subcutaneously. Developed with Wave Life Sciences' advanced oligonucleotide chemistry platform, it is specifically designed to target lung ...

Wave Life Sciences (WVE) shares rallied 74.1% in the last trading session to close at $14.90. This move can be attributable to notable volume with a higher number of shares being traded than in a typical session. This compares to the stock's 49.9% gain over the past four weeks. The sudden rise in the stock price was observed after the company announced positive proof-of-mechanism data, showing first-ever therapeutic RNA editing in humans, from the first single-dose cohort (200 mg) of the phase Ib/IIa Restor ...

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CAMBRIDGE, Mass., Oct. 16, 2024 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, today announced it will host a virtual Research Day on Wednesday, October 30, 2024 at 10:00 a.m. ET (until 11:30 a.m. ET). During the event, Wave will provide an update on its rapidly advancing, wholly owned pipeline, introduce new GalNAc-conjugated RNA editing and siRNA programs, and discuss its ...

CAMBRIDGE, Mass., Oct. 01, 2024 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, announced today that it closed its previously announced underwritten public offering, and that the underwriters exercised in full their option to purchase an additional 3,750,000 of its ordinary shares at the public offering price of $8.00 per ordinary share, less underwriting discounts and commi ...

文章核心观点 - 公司正在进行一次公开发行,预计募集资金约2亿美元 [1][2] - 公司正在发行普通股和预付款认股权证 [1] - 公开发行由摩根大通和利银证券担任联席主承销商 [2] 公司概况 - 公司是一家专注于开发RNA药物的生物技术公司,总部位于剑桥 [5] - 公司的RNA药物平台PRISM结合多种技术,可以开发治疗罕见和常见疾病的候选药物 [5] - 公司的管线包括多个临床项目,如杜氏肌肉营养不良、α1抗胰蛋白酶缺乏症和亨廷顿病,以及一个肥胖症的临床前项目 [5] 融资信息 - 公司计划发行2312.5万股普通股,每股价格8美元 [1] - 此外还将发行187.5万份预付款认股权证,每份价格7.9999美元 [1] - 预计总募集资金约2亿美元,不含承销费用和发行费用 [2] - 承销商还有30天选择权,可额外增发375万股普通股 [2] 发行信息 - 本次发行通过已备案的基础发行文件进行 [3] - 发行文件已在SEC网站公开,投资者可在那里获取 [3] - 发行预计于2024年9月27日完成,但需满足惯常的交割条件 [2]

Shares of Wave Life Sciences (WVE) surged 53.4% on Tuesday after the company announced positive interim data from a mid-stage study evaluating its investigational candidate, WVE-N531, to treat boys with Duchenne muscular dystrophy (DMD) who are amenable to exon 53 skipping. WVE-N531, an exon skipping oligonucleotide, is currently being developed as a disease-modifying treatment for DMD indication in boys. The candidate enjoys the FDA's Orphan Drug and Rare Pediatric Disease designations in the United States ...

CAMBRIDGE, Mass., Sept. 24, 2024 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health, announced today that it has commenced an underwritten public offering of $175 million in aggregate of its ordinary shares, and, to certain investors that so choose in lieu of ordinary shares, pre-funded warrants to purchase ordinary shares. In connection with the offering, Wave intends to grant ...

Mean muscle content-adjusted dystrophin expression of 9.0% and unadjusted dystrophin of 5.5%, with high consistency across participants, in a prespecified analysis; dystrophin was comprised of two isoforms consistent with Becker muscular dystrophy patients who display milder disease Data demonstrated meaningful improvement in serum biomarkers for muscle health, with localization of WVEN531 in myogenic stem cells and regeneration of myofibers Skeletal muscle concentrations of ~41,000 ng/g combined with 61-da ...

Wave Life Sciences Today WVE Wave Life Sciences $5.81 -0.13 (-2.19%) 52-Week Range $3.50 ▼ $7.67 Price Target $12.50 Add to Watchlist The Federal Reserve rate cuts have sent the market up, but some stocks are rising more than others. That includes small pharmaceutical companies like Wave Life Sciences NASDAQ: WVE, whose shares rose 9% the day after the central bank reduced rates by 50 basis points. However, rate cuts are not the only reason for excitement around the company. The average of recent Wall Stree ...