文章核心观点 - 公司开发了一种名为Iomab-ACT的靶向放射性疗法,用于治疗患有镰状细胞病的患者 [4][5] - Iomab-ACT可以在骨髓移植和基因疗法之前用作有针对性的预处理,减少化疗带来的严重毒性反应 [4][5] - 这种创新方法有望最大限度地减少毒性,同时确保完全的供体造血细胞植入 [5] - 这一试验有望为后续的基因疗法预处理研究提供信息,并为镰状细胞病患者提供更广泛的细胞疗法渠道 [4] 根据目录分别总结 公司概况 - 公司是一家开发靶向放射性疗法和其他靶向放射治疗的领导者 [9] - 公司拥有超过230项专利和专利申请,其中包括几项与在回旋加速器中制造Ac-225同位素相关的专利 [9] 产品管线 - 公司的主要产品候选药物包括Iomab-B(预BLA和MAA(欧盟))和Actimab-A(国家癌症研究所CRADA),这些药物已显示出延长复发和难治性急性髓系白血病患者生存期的潜力 [9] - 公司计划推进Iomab-B用于治疗其他血液肿瘤,并推进下一代预处理候选药物Iomab-ACT以改善细胞和基因疗法的结果 [9] 市场机会 - 靶向放射性预处理疗法的市场机会很大,因为所有接受细胞和基因疗法的患者都需要进行某种形式的预处理 [7] - 预计到2030年,美国的CAR-T和基因疗法的可治疗患者人群将近乎翻番,达到约93,000人 [7] - CAR-T疗法市场规模预计未来5年以上将以约11%的复合年增长率增长 [7] - 如果Iomab-ACT能够提供一种或多种临床获益,如降低细胞因子释放综合征(CRS)、减少免疫效应细胞相关神经毒性综合征(ICANS)、延长反应持续时间或提高细胞和基因疗法的整体成功率,那么它就有潜力成为一个潜在的重磅收入机会 [8]

tattywelshie/E+ via Getty Images One of the most eye-watering charts I've seen in a while is the one showing the rise in median prices of homes in the United States over the last ten years, recently touching nearly $435,000. As a parent of children not far off from being on their own, I can certainly sympathize with the frustrations of those who are priced out of the housing market, and I confess that I wonder about whether my children will be able to buy their own homes. Median home price, 2014 - 202 ...

Looking for a stock that has been consistently beating earnings estimates and might be well positioned to keep the streak alive in its next quarterly report? Enact Holdings, Inc. (ACT) , which belongs to the Zacks Insurance - Multi line industry, could be a great candidate to consider.This company has an established record of topping earnings estimates, especially when looking at the previous two reports. The company boasts an average surprise for the past two quarters of 6.97%.For the most recent quarter, ...

RALEIGH, N.C., July 09, 2024 (GLOBE NEWSWIRE) -- Enact Holdings, Inc. (Nasdaq: ACT) (Enact) announced it will issue its second quarter earnings release after the market closes on July 31, 2024. Enact will host a conference call to review second quarter 2024 financial results on August 1, 2024 at 8:00 a.m. (ET). Enact’s earnings release, summary presentation and financial supplement will be available through the company's website, https://ir.enactmi.com/, at the time of their release to the public. Participa ...

RALEIGH, N.C., July 09, 2024 (GLOBE NEWSWIRE) -- Enact Holdings, Inc. (Nasdaq: ACT) (Enact) announced it will issue its second quarter earnings release after the market closes on July 31, 2024. Enact will host a conference call to review second quarter 2024 financial results on August 1, 2024 at 8:00 a.m. (ET). Enact’s earnings release, summary presentation and financial supplement will be available through the company's website, https://ir.enactmi.com/, at the time of their release to the public. Participa ...

RALEIGH, N.C., June 27, 2024 (GLOBE NEWSWIRE) -- Enact Holdings, Inc. (NASDAQ:ACT) (Enact), a leading provider of private mortgage insurance through its insurance subsidiaries, today announced that its flagship legal entity, Enact Mortgage Insurance Corporation, has secured approximately $90 million of additional excess of loss (XOL) reinsurance coverage. This credit risk transfer (CRT) transaction covers a portion of existing mortgage insurance policies written from July 1, 2023 through December 31, 2023 a ...

RALEIGH, N.C., June 27, 2024 (GLOBE NEWSWIRE) -- Enact Holdings, Inc. (NASDAQ:ACT) (Enact), a leading provider of private mortgage insurance through its insurance subsidiaries, today announced that its flagship legal entity, Enact Mortgage Insurance Corporation, has secured approximately $90 million of additional excess of loss (XOL) reinsurance coverage. This credit risk transfer (CRT) transaction covers a portion of existing mortgage insurance policies written from July 1, 2023 through December 31, 2023 a ...

Wall Street’s popular adages are not matching this year. April is historically known as being favorable to investors. But this year, April ended on a disappointing note. For May, the popular adage is “Sell and Go Away.” However, May 2024 turned out highly successful for U.S. stock markets. The three major stock indexes — the Dow, the S&P 500 and the Nasdaq Composite — were up 2.3%, 4.8% and 6.9%, respectively. The tech-heavy Nasdaq Composite recorded its best month since November 2023. On May 31, the blue-c ...

RALEIGH, N.C., June 04, 2024 (GLOBE NEWSWIRE) -- Enact Holdings, Inc. (Nasdaq: ACT) (Enact) today announced that the company’s President and Chief Executive Officer, Rohit Gupta, will participate in a fireside chat at the 2024 TD Financial Services and Fintech Summit on Thursday, June 6, 2024 at 4:15 pm Eastern Time. The fireside chat will be webcast live here, and a replay of the fireside chat can be accessed within 24 hours of the conclusion of the event on the company’s website, https://ir.enactmi.com, u ...

RALEIGH, N.C., May 22, 2024 (GLOBE NEWSWIRE) -- Enact Holdings, Inc. (Nasdaq: ACT) (Enact), today announced that it has priced a registered public offering of $750 million of its 6.25% Senior Notes due 2029 (the “2029 Notes”). The expected settlement date for the offering is May 28, 2024, subject to the satisfaction of customary closing conditions. The 2029 Notes will pay interest semi-annually on May 28 and November 28, beginning November 28, 2024, at a rate of 6.250% per year, maturing May 28, 2029. Enact ...