For the quarter ended June 2024, Charles River Laboratories (CRL) reported revenue of $1.03 billion, down 3.2% over the same period last year. EPS came in at $2.80, compared to $2.69 in the year-ago quarter. The reported revenue compares to the Zacks Consensus Estimate of $1.03 billion, representing a surprise of +0.09%. The company delivered an EPS surprise of +17.15%, with the consensus EPS estimate being $2.39. While investors closely watch year-over-year changes in headline numbers -- revenue and earnin ...

Charles River Laboratories (CRL) came out with quarterly earnings of $2.80 per share, beating the Zacks Consensus Estimate of $2.39 per share. This compares to earnings of $2.69 per share a year ago. These figures are adjusted for non-recurring items. This quarterly report represents an earnings surprise of 17.15%. A quarter ago, it was expected that this medical research equipment and services provider would post earnings of $2.05 per share when it actually produced earnings of $2.27, delivering a surprise ...

收入情况 - 第二季度收入为103亿美元，同比下降3.2%[4] - 第二季度RMS部门收入为2.064亿美元，同比下降1.7%，有机收入下降3.9%[11] - 第二季度DSA部门收入为6.274亿美元，同比下降5.4%，有机收入下降5.0%[13] - 第二季度Manufacturing部门收入为1.923亿美元，同比增长3.1%，有机收入增长3.7%[16] - 公司总收入为20.38亿美元，相比去年同期下降2.5%[31] - 服务收入为16.60亿美元，产品收入为3.78亿美元[31] - 2024年第二季度总收入为1,026,117千美元，相比2023年同期的1,059,937千美元略有下降[49] - 2024年第二季度研发模型和服务收入为206,389千美元，相比2023年同期的209,948千美元略有下降[40] - 2024年第二季度发现和安全评估收入为627,419千美元，相比2023年同期的663,457千美元有所下降[42] - 2024年第二季度制造解决方案收入为192,309千美元，相比2023年同期的186,532千美元有所增长[45] 利润情况 - 第二季度GAAP每股收益为1.74美元，非GAAP每股收益为2.80美元[3] - 第二季度GAAP营业利润率从15.6%降至14.8%，非GAAP营业利润率从20.4%增至21.3%[6] - 第二季度GAAP净利润为9000万美元，同比下降7.2%，非GAAP净利润为1.449亿美元，同比增长4.8%[7] - 净利润为1.69亿美元，相比去年同期下降17.1%[31] - 每股收益（EPS）为3.04美元，相比去年同期下降22.1%[34] - 2024年第二季度非GAAP调整后的运营收入为218,555千美元，相比2023年同期的216,201千美元略有增长[49] 财务指引和预测 - 公司修订了2024年财务指引，预计收入下降4.5%至2.5%，GAAP每股收益为5.65至5.95美元，非GAAP每股收益为9.90至10.20美元[19] - 公司预计通过重组措施实现年度成本节约超过1.5亿美元，其中约1亿美元将在2024年实现[19] 资产和负债情况 - 现金及现金等价物为1.79亿美元，相比去年同期减少35.3%[36] - 总资产为79.48亿美元，相比去年同期减少3.0%[36] - 总负债为41.75亿美元，相比去年同期减少8.4%[38] - 股东权益为37.27亿美元，相比去年同期增长3.5%[38] - 2024年第二季度现金及等价物和限制性现金期末余额为181,004千美元，相比2023年同期的208,777千美元有所减少[39] 股票回购 - 董事会批准了10亿美元的股票回购授权[3] 非GAAP财务指标 - 公司认为补充的非GAAP财务指标提供了有用的信息，使投资者能够对公司的核心运营结果和未来前景有一个有意义的理解[52] - 公司计划继续评估报告非GAAP结果的潜在价值，符合适用的规则、法规和指导[52] - 非GAAP调整包括与收购评估和整合相关的调整，主要包括交易、第三方整合和某些补偿成本，以及与或有对价安排相关的公允价值调整[52] - 第三方法律成本与微生物解决方案业务的环境诉讼和安全评估业务相关的美国政府对NHP供应链的调查有关[52] - 公司认为补充的非GAAP财务指标提供了有用的信息，使投资者能够对公司的核心运营结果和未来前景有一个有意义的理解[59] - 公司计划继续评估报告非GAAP结果的潜在价值，符合适用的规则、法规和指导[59] - 非GAAP调整包括与收购评估和整合相关的调整，主要包括交易、第三方整合和某些补偿成本，以及与或有对价安排相关的公允价值调整[59] - 第三方法律成本与微生物解决方案业务的环境诉讼和安全评估业务相关的美国政府对NHP供应链的调查有关[59] - 公司认为补充的非GAAP财务指标提供了有用的信息，使投资者能够对公司的核心运营结果和未来前景有一个有意义的理解[65] - 公司计划继续评估报告非GAAP结果的潜在价值，符合适用的规则、法规和指导[65] - 非GAAP调整包括与收购评估和整合相关的调整，主要包括交易、第三方整合和某些补偿成本，以及与或有对价安排相关的公允价值调整[65] - 第三方法律成本与微生物解决方案业务的环境诉讼和安全评估业务相关的美国政府对NHP供应链的调查有关[65] 资本支出 - 2024年第二季度资本支出为39,486千美元，相比2023年同期的67,383千美元大幅减少[51]

Charles River Laboratories International, Inc. (CRL) is scheduled to report second-quarter 2024 results on Aug 7, before market open.Earnings Surprise HistoryIn the last reported quarter, the company’s adjusted earnings per share of $2.27 surpassed the Zacks Consensus Estimate by 10.7%. Earnings surpassed estimates in each of the trailing four quarters, the average surprise being 7.92%.Q2 EstimatesThe Zacks Consensus Estimate for revenues is pegged at $1.03 billion, suggesting a 3.3% decline from the year-a ...

文章核心观点 - 查尔斯河实验室(Charles River)与意大利生物技术公司AAVantgarde达成合作,为后者的视网膜色素变性(Stargardt's disease)项目提供GMP质粒DNA生产服务 [1][3][4] - 这次合作将大幅提升查尔斯河实验室的制造解决方案业务 [2] - 查尔斯河实验室在质粒DNA制造方面拥有20年的专业经验,将为AAVantgarde的项目提供支持 [4] - 查尔斯河实验室位于英国基尔的GMP质粒DNA CDMO中心将主导这次合作 [5] 行业概况 - 根据Grand View Research的报告,全球质粒DNA制造市场在2023年价值18亿美元,预计到2030年将以21.01%的复合年增长率增长 [6] - 细胞和基因疗法的兴起推动了行业增长,质粒DNA是基因疗法和疫苗的基础 [7] - 多家公司和研究机构正加快针对基因层面疾病的研发,导致对质粒DNA的需求增加 [8] 公司近期动态 - 上月,查尔斯河实验室与来自德国柏林马克斯·德尔布鲁克中心的自旋公司Captain T Cell合作,开发质粒DNA和逆转录病毒载体 [9] - 查尔斯河实验室的CDMO专业能力还将被科罗拉多大学安斯茨医学校区的盖茨研究所利用,为血液肿瘤的CAR-T细胞疗法开发GMP级慢病毒载体 [10] 股价表现 - 过去一年,查尔斯河实验室股价下跌3%,而行业整体增长4.4% [11] - 公司目前评级为中性(Zacks Rank 3) [12]

Charles River Laboratories’ (CRL) Research Models and Services (RMS) business continues to benefit from the Charles River Accelerator and Development Labs (CRADL) initiative. Yet, the global business environment remains challenging, denting the company’s growth. The stock carries a Zacks Rank #3 (Hold).RMS business services are in high demand among the company’s clients in the field of basic research and screening of non-clinical drug candidates. These service offerings provide greater flexibility for clien ...

Charles River Laboratories International, Inc. (CRL) entered into a lentiviral vector contract development and manufacturing organization (CDMO) agreement with Gates Institute. Per the terms of the deal, Gates Institute will utilize Charles River’s cutting-edge cell and gene therapy CDMO to develop chimeric antigen receptor (CAR) T-cell therapies for hematological cancers.The deal underscores the Gates Institute's mission to provide advanced solutions for cell and gene therapy.With this strategic agreement, ...

Charles River Laboratories International, Inc. (CRL) and Captain T Cell, a spinoff from Max Delbrück Center in Germany, entered into an agreement on plasmid DNA and retrovirus vector production program. Per the terms of the agreement, Captain T Cell will leverage Charles River’s established plasmid and viral vector contract development and manufacturing organization (“CDMO”) capabilities and get access to advisory services. All of these infrastructures are a part of Charles River’s Cell and Gene Therapy Acc ...

Tom Merton/OJO Images via Getty Images This is my second Outlook Therapeutics (NASDAQ:OTLK) article after 04/2023's "Outlook Therapeutics: August PDUFA For Wet AMD Blockbuster". In that article, I pegged Outlook as a high risk high reward bet on a successful PDUFA. I took the bullish bet, rating Outlook a Buy. In doing so, I noted: There is no wiggle room here. What happens if the FDA extends its PDUFA date by three months as quite common? What happens if the FDA issues a CRL? CRL means Complete Respons ...

Charles River Laboratories International, Inc. (CRL) recently announced the launch of its Virtual Control Groups (“VCG”) initiative with Sanofi. The companies are working together to reduce animal usage by replacing selected control group animals with selected matched virtual control animals developed using retrospective datasets.The VCG collaboration is a project guided by Charles River’s Alternative Methods Advancement Project (“AMAP”), an initiative focused on reducing the use of animals in research. The ...