ROCKVILLE, Md. and SUZHOU, China, Nov. 6, 2024 /PRNewswire/ -- Ascentage Pharma (6855.HK), a global biopharmaceutical company engaged in discovering, developing, and commercializing therapies to address global unmet medical needs primarily for malignancies, today announced that the latest results from three clinical studies of one of the company's key drug candidate, lisaftoclax (APG-2575), have been selected for presentations, including an Oral Report, at the 66th American Society of Hematology (ASH) Annua ...

New Phase 1/2 data support the potential of our CAR T-cell therapy candidates, GLPG5101 and GLPG5201, in addressing unmet needs for patients with poor prognoses. Our innovative decentralized cell therapy manufacturing platform delivers fresh, fit cells within a median vein-to-vein time of seven days, with potentially encouraging patient outcomes. Three abstracts, including one oral presentation for GLPG5101 in relapsed/refractory non-Hodgkin lymphoma, and a company showcase, will spotlight our cutting-edge ...

文章核心观点 - 公司宣布在本年度美国血液学会(ASH)年会上将发表超过20篇关于epcoritamab的新临床数据,涵盖多种B细胞恶性肿瘤的各线治疗方案和亚群 [1][2][3] - 这些数据进一步证实了epcoritamab作为单药和联合用药治疗B细胞恶性肿瘤的潜力 [3] - 公司与AbbVie公司合作,致力于推进epcoritamab的全面临床开发计划,为患者提供更多治疗选择 [3] 根据相关目录分别进行总结 口头报告 - 3项口头报告将介绍epcoritamab用于初治弥漫大B细胞淋巴瘤(DLBCL)、大B细胞淋巴瘤(LBCL)和复发/难治性滤泡性淋巴瘤(FL)患者的数据 [2][4][5][6][7] - 1项口头报告将介绍epcoritamab单药治疗复发/难治性慢性淋巴细胞白血病(CLL)患者的结果 [9] - 还将介绍EPCORE® NHL-1试验中epcoritamab用于复发/难治性DLBCL患者3年疗效和安全性数据 [2] 海报报告 - 共有10篇海报报告,涵盖epcoritamab在复发/难治性FL、LBCL和初治DLBCL等多个适应症的临床数据 [10] - 还有5篇电子海报报告,介绍epcoritamab在相关适应症的成本效果分析 [11] 其他 - 公司将于12月11日举办2024年研发更新和ASH数据回顾会议,介绍更多epcoritamab的临床进展 [4] - epcoritamab已在某些淋巴瘤适应症获得监管机构批准,正在多个血液恶性肿瘤适应症进行进一步开发 [12][14][15]

In its upcoming report, Ashland (ASH) is predicted by Wall Street analysts to post quarterly earnings of $1.33 per share, reflecting an increase of 224.4% compared to the same period last year. Revenues are forecasted to be $518.74 million, representing a year-over-year increase of 0.1%.The consensus EPS estimate for the quarter has undergone a downward revision of 3.2% in the past 30 days, bringing it to its present level. This represents how the covering analysts, as a whole, have reassessed their initial ...

- Presentation at ASH will Feature Results from the Phase 2a Trial of SLS009 in Relapsed/Refractory Acute Myeloid Leukemia After Venetoclax Failure – - 50% Response Rate at the Selected Dose Level of 30 mg Twice a Week (BIW) – - 45 mg (Safety Dose) Once a Week of SLS009 Showed a Median Overall Survival (OS) of 5.5 Months vs. <2.5 Months with Standard of Care; 60 mg Once a Week and 30 mg BIW Median OS Not Reached - NEW YORK, Nov. 05, 2024 (GLOBE NEWSWIRE) -- SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) (“S ...

SOUTH SAN FRANCISCO, Calif., Nov. 05, 2024 (GLOBE NEWSWIRE) -- Lyell Immunopharma, Inc. (Nasdaq: LYEL), a clinical-stage company advancing a pipeline of next-generation CAR T-cell therapies for patients with solid tumors or hematologic malignancies, today announced that an abstract highlighting initial clinical data from the Phase 1-2 study of IMPT-314 in large B-cell lymphoma will be presented by Sarah M. Larson, M.D., Associate Professor, Department of Medicine, Medical Director, Immune Effector Cell Ther ...

- CRG-023 is a CD19-, CD20-, CD22-targeting tri-specific CAR T product candidate designed with the goal of providing more patients with a broad range of B-cell malignancies with durable responses by addressing several known causes of relapse, resulting in a potential best-in-class CAR T-cell therapy - - First of its kind, tri-cistronic CAR T to express three independent CARs from a single vector, with each CAR having a distinct co-stimulatory domain – - Data demonstrated sustained anti-tumor activity and a ...

– Ziftomenib combined with 7+3 in 1L NPM1-m or KMT2A-r adverse risk AML patients selected for oral presentation on Saturday, December 7th – – Ziftomenib combined with ven/aza in R/R NPM1-m or KMT2A-r AML patients selected for poster presentation on Sunday, December 8th – SAN DIEGO, Nov. 05, 2024 (GLOBE NEWSWIRE) -- Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, today announced that two abst ...

– Results from Phase 3 ENERGIZE-T Study of Mitapivat in Transfusion-dependent Thalassemia will be Presented in Oral Session – – Tebapivat Phase 1 Data in Sickle Cell Disease and Phase 2b Trial-in-progress Update in Lower-risk Myelodysplastic Syndromes will be Presented and Published – – Live and Webcast Investor Event with Agios Leadership and Medical Experts will be Hosted Onsite on Monday, December 9 – CAMBRIDGE, Mass., Nov. 05, 2024 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader ...

文章核心观点 - 公司宣布将在美国血液学会(ASH)年会上发布Jaypirca(pirtobrutinib)的临床试验数据 [1][2] - Jaypirca是公司开发的一种非共价(可逆)布鲁顿酪氨酸激酶(BTK)抑制剂,用于治疗复发/难治性B细胞恶性肿瘤 [3] 根据目录分别总结 Jaypirca(pirtobrutinib) - BRUIN CLL-321是一项评估Jaypirca与idelalisib联合利妥昔单抗(IdelaR)或苯达莫司汀联合利妥昔单抗(BR)在BTK抑制剂预治疗的慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(CLL/SLL)患者中的随机III期临床试验,该试验之前已达到主要终点 [2] - 公司还将发布关于CLL/SLL患者治疗序列中总生存的真实世界数据分析,以及一种首创的B细胞激活因子受体(BAFF)-RxCD3双特异性抗体LY4152199的临床前数据 [3] 其他 - Jaypirca已获FDA批准用于治疗复发/难治性套细胞淋巴瘤和CLL/SLL患者 [4][5] - 公司正在积极推进Jaypirca和LY4152199的临床开发,以满足B细胞恶性肿瘤患者的未满足医疗需求 [27]