Exhibit 10.1 PREFERRED STOCK PURCHASE AGREEMENT dated as of March 11, 2024 by and among LEXICON PHARMACEUTICALS, INC. and THE PURCHASERS PARTY HERETO TABLE OF CONTENTS Page ARTICLE I PURCHASE; CLOSING 1 Section 1.1 Purchase and Sale 1 Section 1.2 Closing 1 Section 1.3 Closing Conditions 2 Section 1.4 Deliveries 3 ARTICLE II REPRESENTATIONS AND WARRANTIES 4 Section 2.1 Representations and Warranties of the Company 4 Section 2.2 Representations and Warranties of the Purchasers 14 ARTICLE III COVENANTS 16 Sect ...