AC Immune (ACIU) came out with a quarterly loss of $0.25 per share versus the Zacks Consensus Estimate of $0.42. This compares to loss of $0.22 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of -159.52%. A quarter ago, it was expected that this biopharmaceutical company would post a loss of $0.15 per share when it actually produced a loss of $0.21, delivering a surprise of -40%.Over the last four quarters, the company has surpas ...

文章核心观点 - 公司在2024年第二季度取得了重大进展,包括与Takeda签署了ACI-24.060的独家许可协议,获得1亿美元的预付款,并有机会获得最高21亿美元的里程碑付款[2][3][5] - 公司的多个临床和临床前项目进展顺利,包括阿尔茨海默病疫苗ACI-24.060的ABATE II期试验、帕金森病疫苗ACI-7104.056的II期试验以及NLRP3抑制剂ACI-19764的前期研究[5][7][8][11][12] - 公司在2024年第二季度的现金余额为1.752亿瑞士法郎,其中9230万瑞士法郎来自Takeda的付款,预计可维持公司运营3年[13] 根据目录分别总结 财务状况 - 公司2024年6月30日的现金余额为1.752亿瑞士法郎,包括5160万瑞士法郎的现金和现金等价物以及1.236亿瑞士法郎的短期金融资产[13] - 公司的现金余额预计可维持公司运营3年,前提是收到与ACI-35.030入组目标相关的2460万瑞士法郎里程碑付款,且没有其他里程碑付款[13] - 公司2024年第二季度的合同收入为70万瑞士法郎,主要来自与Takeda的合作[13] - 公司2024年第二季度的研发支出为1710万瑞士法郎,较2023年同期增加,主要是由于VacSYn II期试验和ABATE试验的活动增加[13] - 公司2024年第二季度的管理费用增加90万瑞士法郎至460万瑞士法郎,主要是由于业务发展和许可活动相关的法律费用以及股权激励费用的增加[13] 临床和临床前项目进展 - ACI-24.060 ABATE II期阿尔茨海默病疫苗试验入组进展顺利[7] - ACI-7104.056 VacSYn II期帕金森病疫苗试验预计在2024年下半年获得安全性和免疫原性的中期数据[8] - NLRP3抑制剂ACI-19764在前期研究中显示出良好的疗效和安全性,公司计划尽快提交IND申请[5] - 公司的其他临床前项目,如TDP-43 PET探针和α-突触核蛋白PET探针也在有序推进[11][12] 合作和里程碑 - 公司与Takeda签署了ACI-24.060的独家许可协议,获得1亿美元的预付款,并有机会获得最高21亿美元的里程碑付款[5] - 公司董事会和管理层在第二季度增持了公司股票[6]

AC Immune Unveils Novel Therapeutic Antibody Drug Conjugate (ADC) Technology for Improved Efficacy in Neurodegenerative Diseases at AAIC 2024 morADC combines proprietary brain-penetrant small molecule Morphomers® with SupraAntigen® monoclonal antibodies, forming a new class of drug-candidates to target toxic proteins in CNS morADC demonstrated significant synergies, substantially increasing blood brain barrier penetration and potency to inhibit protein aggregation compared to the antibody or small molecule ...

FG Trade/E+ via Getty Images The last time I wrote about AC Immune SA (NASDAQ:ACIU), it was in a Seeking Alpha article entitled “AC Immune: Initial AD Findings Bring About Two Upcoming Catalysts.” In this article, I wrote about the prospects of its anti-Abeta active immunotherapy ACI-24.060 immunotherapy candidate being used to treat patients with Alzheimer's Disease [AD]. The use of this vaccine immunotherapy is currently being explored in the ongoing phase 2 ABATE trial. This trial is split up into ta ...

AC Immune Showcasing its Novel Morphomer-Antibody Drug Conjugate (morADC) Platform for the Treatment of Neurodegenerative Diseases at AAIC 2024 Three oral presentations at the Alzheimer's Association International Conference (AAIC 2024), including talks on morADC, ACI-24.060, and ACI-19626 Lausanne, Switzerland, July 16, 2024 – AC Immune SA (NASDAQ:ACIU), a clinical-stage biopharmaceutical company pioneering precision medicine for neurodegenerative diseases, today announced three oral presentations highligh ...

AC Immune (NASDAQ:ACIU) stock is heading higher on Monday alongside the clinical-stage biopharmaceutical company’s earnings report for the first quarter of 2024. Included in that earnings report is an operational update that covers a new collaboration agreement with Takeda Pharmaceutical (NYSE:TAK). This has Takeda Pharmaceutical signing a licensing agreement for AC Immune’s ACI-24.060. This agreement includes an upfront payment of $100 million to AC Immune. It also covers potential payments of up to $2.1 b ...

Exhibit 99.1 Condensed Consolidated Balance Sheets (Unaudited) (In CHF thousands) As of March 31, December 31, Note 2024 2023 Assets Non-current assets Property, plant and equipment 5 3,236 3,376 Right-of-use assets 6 3,341 3,508 Intangible asset 8 50,416 50,416 Long-term financial assets 6 415 361 Total non-current assets 57,408 57,661 Current assets Prepaid expenses 9 3,917 6,437 Accrued income 3 267 246 Other current receivables 868 622 Accounts receivable 11 — 14,800 Short-term financial assets 10 47,81 ...

AC Immune Reports First Quarter 2024 Financial Results and Provides a Corporate Update Landmark deal announced with Takeda for ACI-24.060 with $100 million upfront and total potential payments for option exercise and milestones of up to approximately $2.1 billion ACI-24.060 ABATE Phase 2 trial on track to report Abeta-PET imaging results in Q2 2024, evaluating amyloid plaque reduction after 6 months of anti-Abeta active immunotherapy ACI-7104.056 VacSYn Phase 2 trial of anti-a-syn active immunotherapy in Pa ...

AC Immune and Takeda Sign Exclusive Option and License Agreement for Active Immunotherapy Targeting Amyloid Beta for Alzheimer's Disease Takeda to receive exclusive option to license global rights to ACI-24.060, a potential first-in-class active immunotherapy designed to delay or slow Alzheimer's disease progression AC Immune to receive upfront payment of $100 million upon closing and be eligible for an option exercise fee and additional potential milestones of up to approximately $2.1 billion AC Immune to ...

, UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F (Mark One) ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☐ SHELL COMPANY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF ...