1 ©2021 KARYOPHARM THERAPEUTICS INC. Investor Conference Call: First Quarter 2021 Financial Results and Business Update May 3, 2021 On Today's Call Prepared Remarks • Michael G. Kauffman, MD, PhD, Co-Founder, Senior Clinical Advisor and Board Member • Mike Mason, MBA, Chief Financial Officer • Richard Paulson, MBA, President and Chief Executive Officer Joining for Q&A Session • John Demaree, MBA, Chief Commercial Officer • Sharon Shacham, PhD, MBA, Chief Scientific Officer • Stephen Mitchener, PharmD, Chief ...