1 ©2021 KARYOPHARM THERAPEUTICS INC. Virtual Investor Day December 8, 2021 Forward-looking Statements and Other Important Information This presentation contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Karyopharm's guidance on its expected cash runway and 2022 revenue and research and development expenses; expectations and plans relating to XPOVIO or any of its drug candidates, if approved, ...