1 ©2022 KARYOPHARM THERAPEUTICS INC. 3) Karyoph A Commercial-Stage Pharmaceutical Company Pioneering Novel Cancer Therapies January 2022 Forward-looking Statements and Other Important Information This presentation contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Karyopharm's preliminary financial information for fourth quarter and full year 2021; guidance on its expected cash runway and 202 ...