1 ©2022 KARYOPHARM THERAPEUTICS INC. First Quarter 2022 Financial Results & Business Update May 5, 2022 On Today's Call • Welcome Elhan Webb, Senior Vice President, Investor Relations • Overview Richard Paulson, President and Chief Executive Officer • Commercial Highlights Sohanya Cheng, Chief Commercial Officer • Pipeline Update Dr. Reshma Rangwala, Chief Medical Officer Dr. Patricia Judson, Senior Vice President, Medical Strategy • Financial Summary and Guidance Michael Mason, Chief Financial Officer • Cl ...