1 ©2023 KARYOPHARM THERAPEUTICS INC. Karyoph Fourth Quarter and Full Year 2022 Financial Results & Business Update February 15, 2023 On Today's Call • Welcome Elhan Webb, CFA, Senior Vice President, Investor Relations • Overview Richard Paulson, President and Chief Executive Officer • Commercial Highlights Sohanya Cheng, Chief Commercial Officer • Pipeline Update Dr. Reshma Rangwala, Chief Medical Officer • Financial Summary and Guidance Michael Mason, Chief Financial Officer • Closing Remarks Richard Pauls ...