TGOM FROM CODE TO CURE® THE TIGIT PATHWAY PVRIG, a Novel Pathway Member Ta r g e t s f o r C a n c e r I m m u n o t h e r a p y : A D e e p D i v e E r a n O p h i r, V P R e s e a r c h & D r u g D i s c o v e r y J u n e 2021 T h e D N A M-1 A x i s • DNAM-1 axis plays an essential role in tumor immunology • PVRIG binds PVRL2 as a functional ligand (TIGIT has a low affinity for PVRL2) 中 • DNAM-1 axis – two parallel dominant complementary inhibitory pathways (PVRIG & TIGIT/CD96?) • TIGIT and PVRIG deliver ...