SECOND QUARTER 2024 FINANCIAL RESULTS AUGUST 1, 2024 ©2024 Vertex Pharmaceuticals Incorporated AGENDA Introduction Susie Lisa, CFA, Senior Vice President, Investor Relations CEO Perspective and Pipeline Update Reshma Kewalramani, M.D., Chief Executive Officer and President Commercial Update Stuart Arbuckle, Executive Vice President and Chief Operating Officer Financial Results Charlie Wagner, Executive Vice President and Chief Financial Officer ©2024 Vertex Pharmaceuticals Incorporated 2 SAFE HARBOR STATEME ...