Exhibit 4.1 CREDIT AGREEMENT dated as of May 1, 2024 by and among MDXHEALTH, INC., as the Borrower, MDXHEALTH SA, as Parent, ORC SPV LLC, as the Initial Lender, and ORC SPV LLC, as the Administrative Agent TABLE OF CONTENTS Page Article I DEFINITIONS AND ACCOUNTING TERMS 1 SECTION 1.1 Defined Terms. 1 SECTION 1.2 Use of Defined Terms 24 SECTION 1.3 Cross-References 24 SECTION 1.4 Accounting and Financial Determinations 24 Article II COMMITMENT AND BORROWING PROCEDURES 24 SECTION 2.1 Commitment 24 SECTION 2. ...