VERTEX FIRST-QUARTER 2021 FINANCIAL RESULTS APRIL 29, 2021 ©2021 Vertex Pharmaceuticals Incorporated global.vrtx.com AGENDA Introduction Michael Partridge, Senior Vice President, Investor Relations CEO Perspective and R&D Update Reshma Kewalramani, M.D., CEO and President Commercial Update Stuart Arbuckle, Executive Vice President and Chief Commercial and Operations Officer Financial Results Charlie Wagner, Executive Vice President and Chief Financial Officer ©2021 Vertex Pharmaceuticals Incorporated global ...